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If 
 is a closed oriented connected 3-Manifold such that every simple closed curve in 
 lies interior to a 
Ball in 
, then 
 is Homeomorphic with the Hypersphere, 
.
See also Ball, Hypersphere
References
Bing, R. H.  ``Necessary and Sufficient Conditions that a 3-Manifold be  
Rolfsen, D.  Knots and Links.  Wilmington, DE: Publish or Perish Press, pp. 251-257, 1976.
 
.''  Ann. Math. 68, 17-37,
  1958.