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de Rham cohomology is a formal set-up for the analytic problem: If you have a Differential
k-Form 
 on a Manifold 
, is it the Exterior Derivative of another Differential k-Form 
? Formally, if 
 then 
. This is more commonly stated
as 
, meaning that if 
 is to be the Exterior Derivative of a Differential k-Form, a Necessary condition that 
 must satisfy is that its Exterior
Derivative is zero.
de Rham cohomology gives a formalism that aims to answer the question, ``Are all differential 
-forms on a Manifold
with zero Exterior Derivative the Exterior Derivatives of 
-forms?'' In
particular, the 
th de Rham cohomology vector space is defined to be the space of all 
-forms with Exterior
Derivative 0, modulo the space of all boundaries of 
-forms.  This is the trivial Vector Space Iff the
answer to our question is yes.
The fundamental result about de Rham cohomology is that it is a topological invariant of the Manifold, namely: the
th de Rham cohomology Vector Space of a Manifold 
 is canonically isomorphic to the
Alexander-Spanier Cohomology Vector Space 
 (also called cohomology with compact support). In
the case that 
 is compact, Alexander-Spanier Cohomology is exactly singular cohomology.
See also Alexander-Spanier Cohomology, Change of Variables Theorem, Differential k-Form, Exterior Derivative, Vector Space