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Let 
 be a Quadrilateral with Perpendicular Diagonals.  The
Midpoints of the sides (
, 
, 
, and 
) determine a Parallelogram (the Varignon
Parallelogram) with sides Parallel to the Diagonals.  The eight-point circle passes
through the four Midpoints and the four feet of the Perpendiculars from the
opposite sides 
, 
, 
, and 
.
See also Feuerbach's Theorem
References
Brand, L.  ``The Eight-Point Circle and the Nine-Point Circle.''  Amer. Math. Monthly 51, 84-85, 1944.
 
Honsberger, R.  Mathematical Gems II.
  Washington, DC: Math. Assoc. Amer., pp. 11-13, 1976.