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Let 
 be a Positive Integer and 
 the number of (not necessarily distinct) Prime Factors of 
(with 
).  Let 
 be the number of Positive Integers 
 with an Odd number of
Prime factors, and 
 the number of Positive Integers 
 with an Even number of
Prime factors.  Pólya conjectured that
The conjecture was made in 1919, and disproven by Haselgrove (1958) using a method due to Ingham (1942).  Lehman
(1960) found the first explicit counterexample, 
, and the smallest counterexample 
 was
found by Tanaka (1980).  The first 
 for which 
 are 
, 4, 6, 10, 16, 26, 40, 96, 586, 
906150256, ... (Tanaka 1980, Sloane's A028488).  It is unknown if 
 changes sign infinitely often (Tanaka 1980).
See also Andrica's Conjecture, Liouville Function, Prime Factors
References
Haselgrove, C. B.  ``A Disproof of a Conjecture of Pólya.''  Mathematika 5, 141-145, 1958.
 
Ingham, A. E.  ``On Two Conjectures in the Theory of Numbers.''  Amer. J. Math. 64, 313-319, 1942.
 
Lehman, R. S.  ``On Liouville's Function.''  Math. Comput. 14, 311-320, 1960.
 
Sloane, N. J. A.  Sequence 
A028488
in ``The On-Line Version of the Encyclopedia of Integer Sequences.''
http://www.research.att.com/~njas/sequences/eisonline.html.
 
Tanaka, M.  ``A Numerical Investigation on Cumulative Sum of the Liouville Function'' [sic].  Tokyo J. Math. 3, 187-189, 1980.