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There exist infinitely many Odd Integers 
 such that 
 is Composite for every 
. Numbers 
 with this property are called Riesel Numbers, and analogous numbers with the minus
sign replaced by a plus are called Sierpinski Numbers of the Second Kind.
The smallest known Riesel number is 
,  but there remain 963 smaller candidates (the smallest of which is 659)
which generate only composite numbers for all 
 which have been checked (Ribenboim 1996, p. 358).
Let 
 be smallest 
 for which 
 is Prime, then the first few values are 2, 0, 2, 1, 1, 2, 3, 1,
2, 1, 1, 4, 3, 1, 4, 1, 2, 2, 1, 3, 2, 7, ... (Sloane's A046069), and second smallest 
 are 3, 1, 4, 5, 3, 26, 7, 2, 4, 3,
2, 6, 9, 2, 16, 5, 3, 6, 2553, ... (Sloane's A046070).
See also Cunningham Number, Mersenne Number, Sierpinski's Composite Number Theorem, Sierpinski Number of the Second Kind
References
Ribenboim, P.  The New Book of Prime Number Records.  New York: Springer-Verlag, p. 357, 1996.
 
Riesel, H.  ``Några stora primtal.''  Elementa 39, 258-260, 1956.
 
Sloane, N. J. A.  Sequences 
A046067,
A046068,
A046069, and
A046070
in ``An On-Line Version of the Encyclopedia of Integer Sequences.''
http://www.research.att.com/~njas/sequences/eisonline.html.