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For the Helmholtz Differential Equation to be Separable in a coordinate system, the Scale Factors 
 in the Laplacian
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(1) | 
| (2) | 
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(3) | 
See also Helmholtz Differential Equation, Laplace's Equation, Separation of Variables, Stäckel Determinant
References
Morse, P. M. and Feshbach, H.  Methods of Theoretical Physics, Part 1.  New York: McGraw-Hill, p. 510, 1953.